• 諮詢熱線+852 3480 8393

Logo
  • 首頁
  • 公司介紹
    • 背景
    • 免疫治療日本
    • 免疫治療香港
    • 腫瘤科醫生
  • 免疫細胞治療
    • 免疫細胞治療/自體免疫療法
    • 樹突狀細胞/DC疫苗療法
    • 自然殺傷細胞/NK細胞療法
    • 淋巴因子活化殺傷細胞(殺手T細胞)療法
    • 免疫治療成功率
    • 免疫治療副作用
    • 免疫治療費用
  • 醫生介紹
    • 日本
    • 香港
  • 癌症預防/防復發
    • 癌症復發率
    • 癌症預防
  • 新聞及臨床報告
    • 新聞
    • 臨床醫學報告
  • 聯絡我們

新聞及臨床報告

  • 首頁
  • 新聞及臨床報告
  • 臨床醫學報告
首頁 > 新聞及臨床報告 > 臨床醫學報告 > Effect of cytokine‑induced killer cells combined with dendritic cells on the survival rate and expression of 14‑3‑3ζ and p‑Bad proteins in Lewis lung cancer cell lines

Effect of cytokine‑induced killer cells combined with dendritic cells on the survival rate and expression of 14‑3‑3ζ and p‑Bad proteins in Lewis lung cancer cell lines

  • Spandidos Publications
  • 2022-06-17
  • 0 次瀏覽

https://www.spandidos-publications.com/10.3892/ol.2018.8834

Abstract

In the present study, the function and mechanism of cytokine‑induced killer cells (CIK) combined with dendritic cells (DC‑CIK) were examined in Lewis lung cancer (LLC) cells. Co‑culture of CIK dendritic cells (DC) in vitro was used to investigate their proliferation and the antitumor effects on LLC cells. DC and CIK cells were collected from healthy human peripheral blood mononuclear cells and co‑cultured as an experimental group, while LLC cells were cultured alone as a control group. Cell morphology was observed by an inverted microscope and an MTT assay was utilized to detect the proliferation of LLC cells. Expression of 14‑3‑3ζ and p‑Bad were measured by western blot analysis. Compared with the control group, treatment of LLC cells with DC‑CIK resulted in decreased cell adherence, reduced cell proliferation and abnormal morphological changes. Additionally, DC‑CIK treatment of LLC cells resulted in the decreased expression of 14‑3‑3ζ and p‑Bad protein in LLC cells, which may provide important information pertaining to the possible mechanism of DC‑CIK‑induced antitumor activity against LLC cells. The present study provides a theoretical and experimental basis for the clinical treatment of DC‑CIK cell co‑culture.


Source: Yang Hou Dongyu Zang Xiaoming Li Fuzhi Li. Effect of cytokine‑induced killer cells combined with dendritic cells on the survival rate and expression of 14‑3‑3ζ and p‑Bad proteins in Lewis lung cancer cell lines

上一篇:Cancer immunotherapy via dendritic cells 下一篇:Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy

欄目分類

  • 新聞 7
  • 臨床醫學報告 13

熱門文章

  • Targeting dendritic cells in pancreatic ductal adenocarcinoma
    2022-06-17
  • Modified Immunotherapy Approach Shows Promise for Leukemia Subscribe
    2022-06-17
  • Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma
    2022-06-17
  • Targeted Cancer Therapy by Dendritic Cell Vaccine
    2022-06-17
  • Dendritic Cell–Based Immunotherapy: State of the Art and Beyond
    2022-06-17
  • Enhancing Dendritic Cell Therapy in Solid Tumors with Immunomodulating Conventional Treatment
    2022-06-17
  • NK cell-based cancer immunotherapy: from basic biology to clinical development
    2022-06-17
  • WT1 (Wilms' Tumor Gene 1): Biology and Cancer Immunotherapy
    2022-06-17
  • Cancer immunotherapy via dendritic cells
    2022-05-05
Logo
  • 郵箱:info@asiaimmune.com
  • 電話:+852 3480 8393

免疫細胞治療

  • 免疫細胞治療/自體免疫療法
  • 樹突狀細胞/DC疫苗療法
  • 自然殺傷細胞/NK細胞療法
  • 淋巴因子活化殺傷細胞(殺手T細胞)療法
  • 免疫治療成功率
  • 免疫治療副作用
  • 免疫治療費用

合作機構

  • 日本新橫濱加藤醫院

公司地址

  • 九龍尖沙咀漢口道28號亞太中心8樓812室
  • +852 3480 8393

Copyright © 2022. Designed by Asia Immunotherapy Company Limited.